求翻译：在开展临床试验前，申请人要紧密结合立题目的，以安全有效性的确定及说明书撰写为基本要求，制定详细的临床试验计划和方案，并依据对阶段性研究结果的评估情况及时进行补充和完善。是什么意思？

Before conducting clinical trials , the applicant should be closely integrated stand subject to determine the safety and effectiveness of written instructions for the basic requirements , develop detailed plans and programs of clinical trials , and based on the findings of the assessment stage timel

In pre-clinical trials, the applicant should, in close conjunction with the topic in order to secure effectiveness and written instructions for the basic requirements, and develop a detailed clinical trial program and the Program, and, on the basis of the stage of research results of the assessment

Before the development clinical test, the applicant must tie closely combines the topic, take the security valid determination and the instruction booklet composition as the basic request, formulates the detailed clinical test plan and the plan, and based on carries on the supplement and the consumm

Before we engage in clinical trials, applicants will need to combine legislation aim to determine the safety and effectiveness of and directions to write as the basic requirements to develop a detailed clinical trial plans and programmes, and on the results of research to assess the situation in tim

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