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关注:1
2013-05-23 12:21
求翻译:By contrast, H3K4me3 is more sharply localized to promoter regions, making it unlikely that the histone mark alone can provide epigenetic inheritance. In addition, mutation of the histone methyltransferase (HMT) activity of MLL in mice results in only mild phenotypes, whereas MLL-null mice die during early embryogenesi是什么意思? 待解决
悬赏分:1
- 离问题结束还有
By contrast, H3K4me3 is more sharply localized to promoter regions, making it unlikely that the histone mark alone can provide epigenetic inheritance. In addition, mutation of the histone methyltransferase (HMT) activity of MLL in mice results in only mild phenotypes, whereas MLL-null mice die during early embryogenesi
问题补充: |
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2013-05-23 12:21:38
相比之下, H3K4me3的更大幅定位于启动子区,因此不太可能单独组蛋白标记能够提供表观遗传。
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2013-05-23 12:23:18
正在翻译,请等待...
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2013-05-23 12:24:58
相反, H3K4me3尖锐地方化到促进者地区,使它不太可能单独组蛋白标记可能提供外成继承。 另外, MLL的组蛋白methyltransferase HMT (活动的) 变化在老鼠导致仅温和的表现型,而在早胚胎形成期间, MLL空老鼠死,表明一个HMT独立作用繁殖活跃染色质states24,190。
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2013-05-23 12:26:38
与此相反的是,H3K4me3 更大幅本地化到启动子区域,使其不可能单独的组蛋白标记可以提供表观遗传。此外,组蛋白甲基转移酶 (HMT) 活性的 MLL 小鼠突变结果只温和型,而 MLL null 小鼠早期胚胎发育,指示一个 HMT 独立函数来传播 190 活性染色质 states24 过程死。
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2013-05-23 12:28:18
正在翻译,请等待...
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