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关注：1
2013-05-23 12:21
求翻译：The overexpression of one of two common MLL fusions, MLL–AF4 and MLL–AF9, which are respectively responsible for AML and acute lymphoid leukaemia (ALL), was shown to modify the normal cell cycle in D. melanogaster 87 and mammals 88. In mammals, MLL–AF4 and MLL–AF9 bind the promoter of the p27 (also known as KIP1 and是什么意思？ 待解决
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The overexpression of one of two common MLL fusions, MLL–AF4 and MLL–AF9, which are respectively responsible for AML and acute lymphoid leukaemia (ALL), was shown to modify the normal cell cycle in D. melanogaster 87 and mammals 88. In mammals, MLL–AF4 and MLL–AF9 bind the promoter of the p27 (also known as KIP1 and
问题补充： |
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2013-05-23 12:21:38
两种常见的MLL融合， MLL- AF4以及MLL- AF9 ，它们分别负责AML和急性淋巴性白血病（ALL ）之一的过量表达，显示出修改正常细胞周期果蝇87和哺乳动物88.
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2013-05-23 12:23:18
正在翻译，请等待...
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2013-05-23 12:24:58
overexpression二共同的MLL融合， MLL-AF4和MLL-AF9之一，负责分别对AML和深刻淋巴腺白血病 (全部)，在D. melanogaster 87和哺乳动物88显示修改正常细胞周期。 在哺乳动物， MLL-AF4和MLL-AF9束缚p27亦称KIP1的 (促进者和CDKN1B) CDKI (cyclindependent激酶 (CDK) 抗化剂)。 然而， p27章程的结果由MLL-AF4取决于细胞类型。 当可诱导MLL-AF4用上皮细胞背景， MLL-AF4被表达downregulates p27的副本，但不其他CDKIs，例如p21 (亦称CIP1， CDKN1A和
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2013-05-23 12:26:38
正在翻译，请等待...
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2013-05-23 12:28:18
正在翻译，请等待...
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