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关注：1
2013-05-23 12:21
求翻译：MLL thus accumulates on chromatin and increases the levels of H3K4me3 on late replication origins, thereby inhibiting chromatin loading of CDC45, an essential component of the prereplication complex necessary for initiation of DNA replication. MLL mutations impair H3K4 trimethylation and allow CDC45 to load onto dam是什么意思？ 待解决
 悬赏分：1
- 离问题结束还有
MLL thus accumulates on chromatin and increases the levels of H3K4me3 on late replication origins, thereby inhibiting chromatin loading of CDC45, an essential component of the prereplication complex necessary for initiation of DNA replication. MLL mutations impair H3K4 trimethylation and allow CDC45 to load onto dam
问题补充： |
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2013-05-23 12:21:38
MLL从而累积在染色质，并增加对晚期的复制起点的H3K4me3的水平，从而抑制CDC45的染色质加载，所必需的DNA复制起始的prereplication复杂的一个基本组成部分。
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2013-05-23 12:23:18
mll从而积聚在与表观遗传学染色质和提高水平的H3K4me3晚到复制来源,从而抑制主虚拟磁盘加载ING与表观遗传学染色质的cdc45,COM的至关重要的主虚拟磁盘前添砖加瓦的主虚拟磁盘复制复杂的启动所需的DNA复制。 mll突变影响H3K4trimethylation和允许CDC45导入到受损与表观遗传学染色质、诱使DNA radioresistant synthesi S(RDS)。
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2013-05-23 12:24:58
MLL在染色质在晚复制起源因而积累并且增加，从而禁止CDC45的染色质装货H3K4me3的水平， prereplication复合体的一个根本组分必要为脱氧核糖核酸复制的启蒙。 MLL变化削弱H3K4 trimethylation并且允许CDC45装载损坏的染色质，导致radioresistant脱氧核糖核酸synthesi s (RDS)。
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2013-05-23 12:26:38
正在翻译，请等待...
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2013-05-23 12:28:18
正在翻译，请等待...
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