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关注:1
2013-05-23 12:21
求翻译:a previously uncharacterized post-transcriptional mechanism may suppress Mdm2 protein without Pict1. The low p53 ubiquitination in Dox+ cells is not simply due to low p53-Mdm2 binding ,and is probably caused by inactivation of the E3 ligase function of Mdm2 induced by loss of Pict1.是什么意思? 待解决
悬赏分:1
- 离问题结束还有
a previously uncharacterized post-transcriptional mechanism may suppress Mdm2 protein without Pict1. The low p53 ubiquitination in Dox+ cells is not simply due to low p53-Mdm2 binding ,and is probably caused by inactivation of the E3 ligase function of Mdm2 induced by loss of Pict1.
问题补充: |
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2013-05-23 12:21:38
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2013-05-23 12:23:18
一个以前遺傳變異后可能抑制transcriptional机制没有pict1 MDM2蛋白质。 P53的低ubiquitination在DOX+细胞不仅仅是由于低p.53-MDM2具有约束力,建筑面积6.5万可能是长癌造成的的E3ligase功能的Mdm2 pict1引起的损失的。
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2013-05-23 12:24:58
一个早先uncharacterized岗位transcriptional机制也许压制Mdm2蛋白质,不用Pict1。 低p53 ubiquitination在Dox+细胞不简单地归结于低p53-Mdm2捆绑和由Mdm2的E3连接酶作用的钝化作用Pict1损失导致的大概造成。
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2013-05-23 12:26:38
以前无特征的转录机制可能禁止未经 Pict1 Mdm2 蛋白。单元格中都喜哈嘎 + 低的 p53 泛并不只是因为要低的 p53 Mdm2 绑定辛苦,可能引起的灭活 E3 连接酶功能的 Mdm2 Pict1 的损失所致。
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2013-05-23 12:28:18
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