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关注：1
2013-05-23 12:21
求翻译：Finally, 12j–12m were achieved from their methyl ester using LiI in refluxing DMF solution. Though several reagents and different conditions were tried, the synthetic process of compound 13 was blocked at the step of etherification of 10l’s 3-position previously. Eventually, our target was carried out through a reversal 是什么意思？ 待解决
 悬赏分：1
- 离问题结束还有
Finally, 12j–12m were achieved from their methyl ester using LiI in refluxing DMF solution. Though several reagents and different conditions were tried, the synthetic process of compound 13 was blocked at the step of etherification of 10l’s 3-position previously. Eventually, our target was carried out through a reversal
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2013-05-23 12:21:38
终于，12J-12M，实现了从他们的甲基酯使用DMF溶液中回流崇礼。尽管一些试剂和不同条件下进行了审判，被挡在化合物13的合成工艺醚一步10升的3位以前。最终，我们的目标是通过反转路线（方案3）。首次合成醚13A根据12米的合成中提到的程序，然后羧基保护，以2 - 烷基-1 ,3-载恶唑-13B线在两个步骤。以下的方法获得了11A，13B变成28位lialh4减少，swern氧化，Wittig反应，先后通过拉长羧基酸13C。耦合与L-苯丙氨酸后，唑啉，甲基酯地deprotected获得羧基13D。最后，我们取得了化合物13在苄集团的存在，通过选择性加氢加入碳酸钠毒害钯催化剂。
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2013-05-23 12:23:18
最后,12j-12m的实现从其甲基酯使用litrefluxingdmf的解决方案。 虽然一些试剂和不同的条件下,合成的复合过程是13这一步时etherification阻塞的10l的3位以前。 最终,我们的目标是通过一个反向路由(计划3)。 乙醚起动助燃装置13a%
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2013-05-23 12:24:58
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2013-05-23 12:26:38
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2013-05-23 12:28:18
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