求翻译：在基本处方的基础上，对影响吡非尼酮脂质体包封率、粒径大小和粒径分布等因素进行单因素考察，选择4个主要因素进行正交设计研究，得到优化的处方和制备工艺。是什么意思？

Single factor, the impact of topiramate non-Nepalese ketone liposome encapsulation efficiency, particle size and particle size distribution and other factors on the basis of the basic prescription, select the four main factors orthogonal design, optimized prescription and preparation process.

In the basic recipe, on the basis of the affected joint, methadone liposomes encapsulating rate, particle size, such as size and particle size distribution with a single factor, factor 4 of the main factors in orthogonal design research, optimization of the prescription and the preparation process.

In the basic prescription foundation, to affects, particle size size and grain-size distribution factors and so on the pyrrole non-Nepal alkone lipin body envelope rate carries on the single factor inspection, chooses 4 primary factors to conduct the orthogonal design research, obtains the optimized

Basic prescription on the basis of, on the effect of non-effect of liposome entrapment, such factors as particle size and particle size distribution for single factors, select the orthogonal design study 4 major factors, optimized recipe and preparation process.

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