求翻译：新药药效学研究技术指导原则指出，新药的主要药效学应在体内、外两种以上实验方法获得证明，其中一种必须是整体的正常或病理动物模型是什么意思？

The new drug pharmacodynamics technical research guidelines pointed out that the new drug pharmacodynamics in vivo and in vitro of two or more experimental methods proved, one of which must be the overall normal or pathologic animal models

New Drug pharmacodynamics research technical guidelines noted that the new drug's primary pharmacodynamics should be in the body, more than two experimental methods to prove that, one of which must be a whole of normal or pathological animal model

The new medicine pharmacodynamics research technical guidance principle pointed out that, new medicine main pharmacodynamics should in vivo, outside two above experimental techniques obtain the proof, one kind must be overall normal or the pathology animal model

Pharmacodynamics research of new technical guidelines pointed out that main pharmacodynamics of drugs should be in in vivo and in vitro experimental methods proved more than two, one must be the overall normal or pathological animal model

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