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关注：1 2013-05-23 12:21

求翻译：In chronic lymphocytic leukemia (CLL) cells, the 48-hr LC50 of AR-42 is 0.76 μM. AR-42 produces dose- and time-dependent acetylation both of histones and tubulin, and induces caspase-dependent apoptosis that is not reduced in the presence of stromal cells. AR-42 significantly reduced leukocyte counts and/or prolonged survival in three separate mouse models of B-cell malignancy without evidence of toxicity. AR-42 has in vitro and in vivo efficacy at tolerable doses. In additon, AR-42 promoted hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. Down-regulation of Kit occurred after AR-42 treatment via inhibition of Kit transcription. [1][2]是什么意思？

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In chronic lymphocytic leukemia (CLL) cells, the 48-hr LC50 of AR-42 is 0.76 μM. AR-42 produces dose- and time-dependent acetylation both of histones and tubulin, and induces caspase-dependent apoptosis that is not reduced in the presence of stromal cells. AR-42 significantly reduced leukocyte counts and/or prolonged survival in three separate mouse models of B-cell malignancy without evidence of toxicity. AR-42 has in vitro and in vivo efficacy at tolerable doses. In additon, AR-42 promoted hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. Down-regulation of Kit occurred after AR-42 treatment via inhibition of Kit transcription. [1][2]
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  • 匿名
2013-05-23 12:26:38
慢性淋巴细胞性白血病 (搭建） 单元格中，48 小时范围 LC50 的 AR-42 是 0.76 μ M。AR-42 产生剂量和时间依赖性乙酰化蛋白和微管蛋白，和凋亡的半胱氨酸蛋白酶依赖，不减少基质细胞在场的情况下。AR-42 大大降低白细胞计数和/或在三个单独的小鼠模型的 B 细胞恶性肿瘤的毒性的证据不长期的生存。AR-42 在容忍剂量的体外和体内的效果。此外，AR-42 晋升的 H3、 H4、 和 α-微管蛋白，hyperacetylation 和 p21 上调。套件下调发生后经套件转录抑制 AR-42 治疗。[] 1[] 2
 
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