求翻译：Although the progress of the art and science of anaesthesia can be viewed as a gradual process since Morton's first anaesthetic in 1846, there was without doubt a quantum leap in 1942 -when Griffith and Johnson introduced curare into clinical practice . Neuromuscular blocking drugs (NMBs) have been in routine use since then but the search for the ideal NMB is almost as old as the story of NMBs itself, for curare had a slow onset, a long duration and a number of undesirable side effects. Progress in the management of neuromuscular blockade has inevitably been intermittent rather than continuous, as the development of this important aspect of anaesthetic practice is dependent on the introduction of new drugs. With each new drug, the management of neuromuscular blockade takes a step forwards, sideways, and occasionally even back a little. This supplement aims to outline the state of the art as it stands today and to ask whether the introduction of sugam-madex, the latest drug in the story of neuromuscularpharmacology, will drive the art and science forwards, sideways or back -is it really time for a change?#是什么意思？

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