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关注:1 2013-05-23 12:21

求翻译:TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase. Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly. TPX2 appears to play a structural role in spindle formation. TPX2 activates Eg2 in a microtubuledependent manner by stimulating the phosphorylation and kinase activity of Eg2. TPX2 is inactivated by binding to importin alpha, a nuclear import factor. Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.是什么意思?

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TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase. Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly. TPX2 appears to play a structural role in spindle formation. TPX2 activates Eg2 in a microtubuledependent manner by stimulating the phosphorylation and kinase activity of Eg2. TPX2 is inactivated by binding to importin alpha, a nuclear import factor. Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.
问题补充:

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2013-05-23 12:26:38
TPX2 (靶蛋白为 Xklp2) 是所涉及的靶向微管运动蛋白 Xklp2 微管相关蛋白。冉 GTP 激活 TPX2 M 阶段的染色质诱导 microbutule 程序集。极光 A 激酶在主轴装置将与 TPX2 和可能通过主轴大会期间的磷酸化调节 TPX2。TPX2 显示主轴形成结构作用。TPX2 激活 Eg2 microtubuledependent 的方式,通过刺激的磷酸化及 Eg2 激酶活性。TPX2 是通过绑定到 importin alpha,核导入因子灭活。最后,TPX2 RNA 干扰抑制导致在细胞有丝分裂过程中的微管组织中的缺陷。
 
 
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