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关注：1 2013-05-23 12:21

求翻译：Phosphodiesterases are a superfamily of enzymes that hydrolyze cAMP and/or cGMP and thereby regulate the intracellular levels of second messengers [6]. Members of PDE4 family (E.C. 3.1.4.17) are cAMP-specific PDEs composed of number of isoforms and are highly represented in the lung [7-10]. As a component of cAMP/protein kinase A (PKA) pathway PDE4 plays direct role in cell proliferation, differentiation and migration through regulation of the cAMP level [11-13]. Finally, PDE4 represents the major cAMP-hydrolyzing enzyme in monocytes, lymphocytes and neutrophils and its activation is required for inflammatory response [8,14,15].是什么意思？

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Phosphodiesterases are a superfamily of enzymes that hydrolyze cAMP and/or cGMP and thereby regulate the intracellular levels of second messengers [6]. Members of PDE4 family (E.C. 3.1.4.17) are cAMP-specific PDEs composed of number of isoforms and are highly represented in the lung [7-10]. As a component of cAMP/protein kinase A (PKA) pathway PDE4 plays direct role in cell proliferation, differentiation and migration through regulation of the cAMP level [11-13]. Finally, PDE4 represents the major cAMP-hydrolyzing enzyme in monocytes, lymphocytes and neutrophils and its activation is required for inflammatory response [8,14,15].
问题补充：
  • 匿名
2013-05-23 12:26:38
磷酸二酯酶是家族的酶水解营和 （或） cGMP，从而调节细胞内第二信使 [6] 的水平。PDE4 家庭 (欧洲共同体 3.1.4.17） 的成员是营特定偏微分方程的亚型数的组成和高度在肺 [7-10] 中表示。作为营/蛋白激酶 A (PKA) 组件通路 PDE4 细胞增殖、 分化和迁移通过 cAMP 的水平 [11-13] 条进行了直接作用。最后，PDE4 表示主要营水解酶在单核细胞、 淋巴细胞和中性粒细胞和其激活是必需的炎症反应 [8,14,15]。
 
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