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关注：1
2013-05-23 12:21
求翻译：For these reasons, PDE4 inhibitors were suggested for treatment of several lung diseases as new anti-inflammatory and anti-remodeling agents [16]. Our group has previously demonstrated that PDE3/4 inhibitor attenuates migration of pulmonary artery smooth muscle cells (PASMCs) in vitro and reverses pulmonary vascular remodeling in vivo [17]. PDE4 inhibitor cilomilast was also shown to suppress the release and activation of MMP-1 and MMP-9 from lung fibroblasts, which are known to be involved in PF progression [18]. Furthermore, cilomilast and other PDE4 inhibitors were demonstrated to inhibit lung TNF-α and TGF-β release, as well as neutrophil influx in vivo [19-21]. Finally, treatment of experimental chronic colitis with PDE4 inhibitor rolipram resulted in decreased collagen deposition as well as TNF-α and TGF-β content in the tissue [22].是什么意思？ 待解决
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- 离问题结束还有
For these reasons, PDE4 inhibitors were suggested for treatment of several lung diseases as new anti-inflammatory and anti-remodeling agents [16]. Our group has previously demonstrated that PDE3/4 inhibitor attenuates migration of pulmonary artery smooth muscle cells (PASMCs) in vitro and reverses pulmonary vascular remodeling in vivo [17]. PDE4 inhibitor cilomilast was also shown to suppress the release and activation of MMP-1 and MMP-9 from lung fibroblasts, which are known to be involved in PF progression [18]. Furthermore, cilomilast and other PDE4 inhibitors were demonstrated to inhibit lung TNF-α and TGF-β release, as well as neutrophil influx in vivo [19-21]. Finally, treatment of experimental chronic colitis with PDE4 inhibitor rolipram resulted in decreased collagen deposition as well as TNF-α and TGF-β content in the tissue [22].
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2013-05-23 12:26:38
出于这些原因，作为新的抗炎、 抗重构代理 [16] 几种肺疾病的治疗建议有 PDE4 抑制剂。我们组以前表明 PDE3/4 抑制剂抑制肺血管平滑肌细胞 （与肺动脉) 体外迁移反转肺血管重塑体内 [17]。PDE4 抑制剂 cilomilast 也是压抑的释放和肺成纤维细胞，被公认为参与 PF 进展 [18] 从激活的基质金属蛋白酶-1、 基质金属蛋白酶-9 所示。此外，cilomilast 和其他 PDE4 抑制剂已被证明抑制肺肿瘤坏死因子-α 和 TGF-β 的发布，以及中性粒细胞大量涌入体内 [19-21]。最后，PDE4 抑制剂咯利普兰实验慢性结肠炎治疗导致减少的胶原沉积以及 [22] 组织中肿瘤坏死因子-α 和 TGF-β 的内容。
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