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  • 匿名
关注:1 2013-05-23 12:21

求翻译:Indeed, cilomilast was the most potent at early stage (days 4 and 7) of bleomycin-induced PF, when inflammation is the major characteristic of the pathological process [5]. Total number of alveolar inflammatory cells in BALF of treated mice was significantly reduced, as well as number of macrophages and lymphocytes. These results are consistent with the fact that PDE4 expression is induced by inflammatory stimulus and that it mediates activation and proliferation of T-cells and function of macrophages [25-28]. In turn, macrophages represent the major inflammatory cell type in alveolus, thereby strongly influencing total cell count values [29,30].是什么意思?

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Indeed, cilomilast was the most potent at early stage (days 4 and 7) of bleomycin-induced PF, when inflammation is the major characteristic of the pathological process [5]. Total number of alveolar inflammatory cells in BALF of treated mice was significantly reduced, as well as number of macrophages and lymphocytes. These results are consistent with the fact that PDE4 expression is induced by inflammatory stimulus and that it mediates activation and proliferation of T-cells and function of macrophages [25-28]. In turn, macrophages represent the major inflammatory cell type in alveolus, thereby strongly influencing total cell count values [29,30].
问题补充:

  • 匿名
2013-05-23 12:26:38
Cilomilast 实际上,在早期阶段是最有力 (4 和 7 天) 的博莱霉素致 PF,当炎症病理过程 [5] 的主要特征。支气管肺泡灌洗液治疗小鼠肺泡炎性细胞总数明显降低,以及淋巴细胞和巨噬细胞的数量。这些结果都符合这一事实 PDE4 表达诱发炎症的刺激和它介于激活和 T 细胞的增殖和巨噬细胞 [25-28] 功能。反过来,巨噬细胞表示主要炎症细胞类型在肺泡,从而强烈影响总细胞计数值 [29,30]。
 
 
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