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关注：1
2013-05-23 12:21
求翻译：To find if general suppression of inflammatory cells release was also reflected in lung inflammatory cytokines expression, expression of TNF-α, IL-1β and IL-6 was analyzed at the same time points as the cell count experiments were done. These markers are upregulated in the lungs of both humans and mice with PF and are the canonical cytokines expressed at first days 4-7 of experimental PF [2-5]. We demonstrated significantly lower TNF-α expression in the lungs of mice treated with cilomilast compared to those received placebo. Taking into account lower numbers of BALF macrophages after cilomilast treatment it was expected to see downregulation of TNF-α as macrophages represent one of the major sources of this cytokine [2]. Similar effects of cilomilast were also shown by other authors [19].是什么意思？ 待解决
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- 离问题结束还有
To find if general suppression of inflammatory cells release was also reflected in lung inflammatory cytokines expression, expression of TNF-α, IL-1β and IL-6 was analyzed at the same time points as the cell count experiments were done. These markers are upregulated in the lungs of both humans and mice with PF and are the canonical cytokines expressed at first days 4-7 of experimental PF [2-5]. We demonstrated significantly lower TNF-α expression in the lungs of mice treated with cilomilast compared to those received placebo. Taking into account lower numbers of BALF macrophages after cilomilast treatment it was expected to see downregulation of TNF-α as macrophages represent one of the major sources of this cytokine [2]. Similar effects of cilomilast were also shown by other authors [19].
问题补充： |
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2013-05-23 12:26:38
若要找到如果一般抑制炎症细胞释放也反映在肺炎症细胞因子的表达，表达肿瘤坏死因子-α、 白细胞介素-1β 和白细胞介素-6 分析在相同的时间点细胞计数实验是这样做。这些标记是人类和 PF 小鼠肺内的增高，表示在第一天 4-7 的实验 PF [2-5] 典型的细胞因子。我们展示了与 cilomilast 相比，那些接受安慰剂治疗小鼠肺部显著降低肿瘤坏死因子-α 表达。它期待看到肿瘤坏死因子-α 表达下调，如巨噬细胞代表此细胞因子 [2] 的主要来源之一的 cilomilast 治疗后支气管肺泡灌洗液巨噬细胞低数字考虑到。Cilomilast 类似影响还显示其他作者 [19]。
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