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  • 匿名
关注:1 2013-05-23 12:21

求翻译:Besides inflammation, PF is characterized by tissue remodeling and accumulation of extracellular matrix components. This ultimately results in impairment of gas exchange due to thickened interstitium and in worsening of lung mechanical properties due to increasing stiffness of the tissue [1]. As expected, decreased pulmonary compliance, higher fibrosis degree and higher lung collagen level were observed at days 14 and 24 in mice that received instillation of bleomycin. Progression of fibrosis is illustrated by lower compliance and higher fibrosis score at day 24 compared to day 14. Typical manifestations of bleomycin-induced PF, such as patchy pattern and interstitial inflammation were also observed.是什么意思?

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Besides inflammation, PF is characterized by tissue remodeling and accumulation of extracellular matrix components. This ultimately results in impairment of gas exchange due to thickened interstitium and in worsening of lung mechanical properties due to increasing stiffness of the tissue [1]. As expected, decreased pulmonary compliance, higher fibrosis degree and higher lung collagen level were observed at days 14 and 24 in mice that received instillation of bleomycin. Progression of fibrosis is illustrated by lower compliance and higher fibrosis score at day 24 compared to day 14. Typical manifestations of bleomycin-induced PF, such as patchy pattern and interstitial inflammation were also observed.
问题补充:

  • 匿名
2013-05-23 12:26:38
除了炎症,PF 的特点是组织重构和细胞外基质成分积累。这最终结果中的气体交换,由于以加厚间质损害和应付刚度的 [1] 组织增加肺力学性能恶化。如预期,减少肺法规遵从性,在 14 和收到博莱霉素灌注的小鼠 24 天看到了组织纤维化程度更高和更高肺胶原水平。较低的法规遵从性和纤维化分数越高说明的纤维化进展在天 24 天 14 相比。博莱霉素诱导的 PF,修修补补的模式和间质炎症等典型表现还观察到。
 
 
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