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  • 匿名
关注：1 2013-05-23 12:21

求翻译：Based on our observations and the results of other authors we suppose that inhibition of PDE4 affects both general aspects of PF, namely inflammation and tissue remodeling itself. At first, PDE4 inhibition suppresses tissue fibrosis by partial elimination of pro-fibrotic environment, for instance by suppression of inflammatory cells infiltration, downregulation of TNF-α and stimulation of IL-6 expression shown in the present work. TNF-α secreted by macrophages [2,36] is a direct mitogen for lung fibroblasts [37] and its inhibition can be alone sufficient to attenuate PF [38]. Moreover, it was shown that PDE4 itself is necessary for TNF-α production and development of inflammatory response [15,25].是什么意思？

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Based on our observations and the results of other authors we suppose that inhibition of PDE4 affects both general aspects of PF, namely inflammation and tissue remodeling itself. At first, PDE4 inhibition suppresses tissue fibrosis by partial elimination of pro-fibrotic environment, for instance by suppression of inflammatory cells infiltration, downregulation of TNF-α and stimulation of IL-6 expression shown in the present work. TNF-α secreted by macrophages [2,36] is a direct mitogen for lung fibroblasts [37] and its inhibition can be alone sufficient to attenuate PF [38]. Moreover, it was shown that PDE4 itself is necessary for TNF-α production and development of inflammatory response [15,25].
问题补充：
  • 匿名
2013-05-23 12:26:38
根据我们的观察和其他作者的结果我们假设 PDE4 抑制影响 PF，即炎症和组织重构本身这两个一般方面。第一，在 PDE4 抑制抑制组织纤维化的 pro 肝纤维化的环境中，部分消除例如抑制炎症细胞的浸润、 肿瘤坏死因子-α 表达下调和白细胞介素-6 表达现在的工作中所示的刺激。[2,36] 巨噬细胞分泌肿瘤坏死因子-α 是直接丝裂肺成纤维细胞 [37] 和其抑制作用可以是独自一人足以衰减 PF [38]。此外，它所示，PDE4 本身就是肿瘤坏死因子-α 生产和炎症反应 [15,25] 发展所必需的。
 
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