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  • 匿名
关注:1 2013-05-23 12:21

求翻译:RA patients on immunosuppressive therapy are at an increased risk of developing lower respiratory tract infections, particularly if they have pre-existing lung disease. Many infectious organisms, including mycobacterium avium, mycobacterium tuberculosis, and pneumocystis jirovecii, as well as fungal pathogens can have a radiologic appearance that mimics RA-ILD with increased ground glass and interstitial infiltrates. An additional consideration is that chronic prednisone use increases the risk of hospitalization for pneumonia in RA patients in a dose-dependent fashion with doses greater than 10mg/day more than doubling the risk [38]. Another study highlighted an increased risk of pneumocystis pneumonia in patients taking as little as 15mg of prednisone per day for more than 8 weeks suggesting that the use of trimethoprim-sulfamethoxazole as prophylaxis in these patients may be beneficial [39].是什么意思?

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RA patients on immunosuppressive therapy are at an increased risk of developing lower respiratory tract infections, particularly if they have pre-existing lung disease. Many infectious organisms, including mycobacterium avium, mycobacterium tuberculosis, and pneumocystis jirovecii, as well as fungal pathogens can have a radiologic appearance that mimics RA-ILD with increased ground glass and interstitial infiltrates. An additional consideration is that chronic prednisone use increases the risk of hospitalization for pneumonia in RA patients in a dose-dependent fashion with doses greater than 10mg/day more than doubling the risk [38]. Another study highlighted an increased risk of pneumocystis pneumonia in patients taking as little as 15mg of prednisone per day for more than 8 weeks suggesting that the use of trimethoprim-sulfamethoxazole as prophylaxis in these patients may be beneficial [39].
问题补充:

  • 匿名
2013-05-23 12:26:38
RA 患者免疫抑制治疗在下呼吸道感染的风险增加,特别是如果他们有预先存在的肺疾病。很多的传染性生物,包括分枝杆菌、 结核分枝杆菌和卡氏肺 jirovecii 病原真菌的研究可以具有模仿 RA 中联部增加地面玻璃的放射学外观和间质浸润。另一个考虑因素是慢性泼尼松使用增加剂量大于 10 毫克/天增长逾一倍 [38] 风险的剂量依赖性时尚 RA 患者肺炎住院的风险。另一项研究强调了卡氏肺肺炎患者泼尼松超过 8 个星期暗示新诺明用作预防这些患者可能有益 [39] 每天 15 毫克,只增加的风险。
 
 
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