求翻译：Saravanan and Kelly found that the greatest predictor for the development of pneumonitis is pre-existing pulmonary disease, with a baseline abnormality in the diffusing capacity less than 70% of predicted incurring a 10-fold increased risk of MTX drug toxicity [50]. Tobacco abuse, hypoalbuminemia, and previous use of DMARDs including sulfasalazine, gold salts, or D-penicillamine also have large attributable risks [51]. Minor risk factors including advanced age, diabetes mellitus, and RA pleuropulmonary involvement increase the risk for MTX pneumonitis [37, 52, 53]. Our current recommendation is to obtain pulmonary function tests prior to the institution of MTX, and if the DLCO is less than 70% of predicted, and an HRCT shows any evidence of pleural or interstitial thickening that another agent considered.是什么意思？

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