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关注：1
2013-05-23 12:21
求翻译：Over-expression of matrix metalloproteinases by lung fibroblasts has been blamed for much of the tissue destruction associated with airway inflammation. Because cyclic AMP is known to regulate fibroblast proliferation, as well as cytokine and extracellular matrix protein production, the current study was designed to evaluate the ability of three selective phosphodiesterase (PDE) type 4 inhibitors, rolipram, cilomilast and CI-1044, to inhibit extracellular matrix degradation. Using zymography and ELISA, we found that pro-MMP-2 release was enhanced following 24 h treatment of human lung fibroblast (MRC-5) with TGF-beta1 (10 ng/ml) or TNF-alpha (10 ng/ml), whereas PMA (0.02 microM) had no effect.是什么意思？ 待解决
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- 离问题结束还有
Over-expression of matrix metalloproteinases by lung fibroblasts has been blamed for much of the tissue destruction associated with airway inflammation. Because cyclic AMP is known to regulate fibroblast proliferation, as well as cytokine and extracellular matrix protein production, the current study was designed to evaluate the ability of three selective phosphodiesterase (PDE) type 4 inhibitors, rolipram, cilomilast and CI-1044, to inhibit extracellular matrix degradation. Using zymography and ELISA, we found that pro-MMP-2 release was enhanced following 24 h treatment of human lung fibroblast (MRC-5) with TGF-beta1 (10 ng/ml) or TNF-alpha (10 ng/ml), whereas PMA (0.02 microM) had no effect.
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2013-05-23 12:26:38
被指责的肺成纤维细胞基质金属蛋白酶的表达与气道炎症相关联的组织破坏的大部分时间。因为所知环磷酸腺苷调节碱性成纤维细胞增殖及细胞因子和细胞外基质蛋白生产，目前的研究旨在评估三个选择性磷酸二酯酶 (PDE) 类型 4 抑制，咯利普兰、 cilomilast 和 CI-1044，抑制细胞外基质降解的能力。利用酶和酶联免疫吸附试验，我们发现 pro-基质金属蛋白酶-2 释放增强后的人肺成纤维细胞 (mrc-5) 24 小时处理与 TGF beta1 (10 吴/ml） 或肿瘤坏死因子-α (10 吴/ml），而 PMA (0.02 microM） 并无影响。
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