求翻译：创伤和各种疾患导致数量巨大的患者需要接受组织修复重建手术，而组织修复材料的来源一直是极具挑战性的临床问题。是什么意思？

Trauma and disease led to a huge number of patients in need of repair and reconstruction of organizational operation and source of tissue repair materials have always been very challenging clinical problem.