求翻译：美国国立研究院（NRC）描绘了具有划时代意义的21世纪毒理学的前景，即Toxicity Testing in the 21st Century: A Vision and a Strategy，提出毒理学应当由原来的体内动物研究向体外试验转变。这是一篇影响深远的文章，指出毒理学试验和风险评价策略应重点放在“毒性作用路径”这一科学理念的基础上，生物体是一个复杂系统，只有将在基因、蛋白质等不同水平上观察到的各种相互作用、代谢途径、调控通路的改变综合起来，才能全面、系统地阐明复杂的毒性效应（图），因此，导致传统毒理学向系统毒理学(systems toxicdogy)发展。是什么意思？

United States National Research Centre (NRC) depicts a landmark of the 21st century prospects for toxicology, namely Toxicity Testing in the 21st Century:A Vision and a Strategy, toxicology should be from the original proposed change in vivo animal studies to the in vitro test. This is a article effect far-reaching of article, pointed out that HIV neo test and risk evaluation policy should focus placed in "toxicity role path" this a science concept of Foundation Shang, organisms is a complex system, only will in gene, and protein, different level Shang observation to of various mutual role, and metabolism way, and regulation pathway of change integrated up, to full, and system to stated complex of toxicity effect (figure), therefore, led traditional HIV neo to System HIV neo (systems toxicdogy) development.