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关注:1
2013-05-23 12:21
求翻译:This showed that the promoters of neural genes are bivalent and repressed in ES cells. During differentiation into NPCs, they lose the H3K27me3 modifications and retain the H3K4me3 marks, resulting in increased expression 161. The resolution of bivalency is achieved by active H3K27me3-specific demethylation, downreg是什么意思? 待解决
悬赏分:1
- 离问题结束还有
This showed that the promoters of neural genes are bivalent and repressed in ES cells. During differentiation into NPCs, they lose the H3K27me3 modifications and retain the H3K4me3 marks, resulting in increased expression 161. The resolution of bivalency is achieved by active H3K27me3-specific demethylation, downreg
问题补充: |
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2013-05-23 12:21:38
这表明神经基因的启动子是二价和压抑在ES细胞。
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2013-05-23 12:23:18
正在翻译,请等待...
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2013-05-23 12:24:58
这表示,神经系统的基因的促进者是二价和抑制在ES细胞。 在分化期间到NPCs里,他们丢失H3K27me3修改并且保留H3K4me3标记,造成增加的表示161。 bivalency的决议由活跃H3K27me3具体zeste同源染色体2 EZH2 methyltransferase改进物的demethylation、downregulation (和) 动态开关在个人计算机目标达到162-166。 另外, RBBP5和DPY30,指南针象复合体二个组分,为ES细胞的分化是必要的入NPCs。
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2013-05-23 12:26:38
这表明神经基因的启动子是二价和压抑胚胎干细胞。在分化为 Npc,期间他们失去 H3K27me3 修改,保留 H3K4me3 标记,导致表达增加 161。细化该决议被通过去甲基化 H3K27me3 特定活动、 下调 zeste 同系物 2 剂甲基转移酶 (EZH2) 和动态开关在 Pc 目标 162-166。此外,RBBP5 和 DPY30,两个组件的罗盘状复合体,是在胚胎干细胞分化为 Npc 的必要条件。
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2013-05-23 12:28:18
正在翻译,请等待...
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